Detalle del registro

Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats

Universidad Católica Argentina

 
Autor Cardinali, Daniel P.
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
 
Fecha 2013
 
Descripción Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases
 
Formato application/pdf
 
Enlace http://bibliotecadigital.uca.edu.ar/repositorio/investigacion/melatonin-may-curtail-metabolic-syndrome.pdf
 
Idioma eng
 
Derechos Los autores han autorizado al Sistema de Bibliotecas de la Universidad Católica Argentina a divulgar en línea la presente obra.
 
Tema SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
 
Título Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats
 
Tipo Artículo