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Positive association between conflicts of interest and reporting of positive results in randomized clinical trials in dentistry

Universidad de Chile. Repositorio Académico

 
Título Positive association between conflicts of interest and reporting of positive results in randomized clinical trials in dentistry
 
Autor
Yanine Montaner, Nicolás Ignacio
Araya Cabello, Ignacio Andrés
Villanueva Maffei, Julio Alberto
Carrasco Labra, Alonso
Pintor, Fernanda
Cornejo Ovalle, Marco
Ulloa Marín, Carolina Elliet
Brignardello Petersen, Romina
 
Tema Conflict of interest
 
Descripción Artículo de publicación ISI
Background. The relationship between industry funding and
study results has been explored widely in medicine but not in
dentistry. The authors aimed to assess the relationship between
conflicts of interest (COIs) and study results.
Methods. The authors assessed all randomized clinical trials
(RCTs) published between July 2010 and June 2012 in the 10
dental journals with the highest impact factors in dentistry. The
authors used three definitions of COI and explored their associations
with positive study results.
Results. Depending on the definition of COI, the odds ratio
for reporting positive results varied between 2.40 (95 percent
confidence interval [CI], 1.16-5.13) and 9.19 (95 percent CI, 1.71-
170.64). The authors found no association between positive study
results and journal of publication or area of practice.
Conclusions. RCTs in which authors have some type of COI are
more likely to have results that support the intervention being
assessed.
Practical Implications. When reviewing the results of RCTs,
clinicians need to be aware of the association between reporting
positive study results and the type of COI disclosure and be
even more careful when critically appraising and applying their
results.
 
Fecha 2014-01-14T13:42:28Z
2015-03-12T17:51:43Z
2014-01-14T13:42:28Z
2015-03-12T17:51:43Z
2013
 
Tipo Artículo de revista
 
Enlace JADA 2013;144(10):1165-1170
http://repositorio.uchile.cl/handle/2250/123511
 
Idioma en
 
Derechos Attribution-NonCommercial-NoDerivs 3.0 Chile
http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
 
Publicador American Dental Association